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One-Pot Synthesis of Luotonin A and Its Analogues

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journal contribution
posted on 04.03.2011, 00:00 by Ming-Chung Tseng, Yu-Wan Chu, Hsiang-Ping Tsai, Chun-Mao Lin, Jaulang Hwang, Yen-Ho Chu
Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.