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One-Pot Synthesis of Indole-Fused Scaffolds via Gold-Catalyzed Tandem Annulation Reactions of 1,2-Bis(alkynyl)-2-en-1-ones with Indoles

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journal contribution
posted on 22.02.2016, 17:11 by Xin Xie, Xiangwei Du, Yifeng Chen, Yuanhong Liu
The gold-catalyzed tandem cyclization of 1,2-bis(alkynyl)-2-en-1-ones with indoles offers an efficient and straightforward route to indole-fused polycyclic systems. The process is realized through a cascade carbonyl-yne cyclization/Friedel–Crafts/indole-yne cyclization sequence catalyzed by a single-pot catalyst of gold.