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One-Pot Synthesis of Diarylalkynes Using Palladium-Catalyzed Sonogashira Reaction and Decarboxylative Coupling of sp Carbon and sp2 Carbon

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journal contribution
posted on 06.03.2008, 00:00 by Jeongju Moon, Miso Jeong, Hyungoog Nam, Jinhun Ju, Joong Ho Moon, Hyun Min Jung, Sunwoo Lee
Decarboxylative coupling of sp-sp2 carbons is possible by palladium catalyst. Employing propiolic acid (1) as a difunctional alkyne, and using the consecutive reactions of the Sonogashira reaction and the decarboxylative coupling, unsymmetrically substituted diaryl alkynes were obtained in moderate to good yield.