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One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

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journal contribution
posted on 2009-10-02, 00:00 authored by Yu Sung Chun, Ka Yeon Ryu, Young Ok Ko, Joo Yeon Hong, Jongki Hong, Hyunik Shin, Sang-gi Lee
The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields