One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

Chun, Yu Sung; Ryu, Ka Yeon; Ko, Young Ok; Hong, Joo Yeon; Hong, Jongki; Shin, Hyunik; Lee, Sang-gi

doi:10.1021/jo901642t.s001

jo901642t_si_001.pdf (1.07 MB)

One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

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posted on 2009-10-02, 00:00 authored by Yu Sung Chun, Ka Yeon Ryu, Young Ok Ko, Joo Yeon Hong, Jongki Hong, Hyunik Shin, Sang-gi Lee

The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields

One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

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