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One-Pot Syntheses of 2,3-Dihydrothiopyran-4-one Derivatives by Pd/Cu-Catalyzed Reactions of α,β-Unsaturated Thioesters with Propargyl Alcohols

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journal contribution
posted on 19.06.2008, 00:00 by Yasunori Minami, Hitoshi Kuniyasu, Nobuaki Kambe
2,3-Dihydrothiopyran-4-one derivatives were readily prepared by Pd/Cu-catalyzed reactions between α,β-unsaturated thioesters and propargyl alcohols in the presence of bases. Of note, both carbon−sulfur bonds were cleaved as a result of the single procedure.