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One-Pot Selective Homodimerization/Hydrogenation Strategy for Sequential Dicarba Bridge Formation

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journal contribution
posted on 18.09.2015, 00:00 by James Burnley, W. Roy Jackson, Andrea J. Robinson
The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt–carbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis.