ol6b00309_si_001.pdf (6.85 MB)
One-Pot Regiospecific Synthesis of Quinoxalines via a CH2‑Extrusion Reaction
journal contribution
posted on 2016-02-29, 16:04 authored by Jinhai Shen, Xiangdong Wang, Xing Lin, Zhenhui Yang, Guolin Cheng, Xiuling CuiA convenient
“one-pot” regiospecific synthesis of
substituted quinoxalines from o-phenylenediamines
and ynones under metal-free conditions has been developed. An intermolecular
Michael addition reaction, a dehydration condensation, and a base-promoted
C-α-CH2-extrusion were involved in this procedure,
which features high regioselectivity, efficiency, and environmental
friendliness. Various quinoxalines were provided in up to 95% yield
for 33 examples.
