One-Pot Homolytic Aromatic Substitutions/HWE Olefinations under Microwave Conditions for the Formation of a Small Oxindole Library
journal contributionposted on 30.09.2004, 00:00 by Antje Teichert, Katja Jantos, Klaus Harms, Armido Studer
An efficient one-pot sequence comprising a homolytic aromatic substitution followed by an ionic Horner−Wadsworth−Emmons olefination for the preparation of a small library of α,β-unsaturated oxindoles is presented. Microwave-induced heating is used to conduct these reactions. The homolytic aromatic substitution is mediated by the persistent radical effect.