One-Pot Asymmetric Synthesis of 2- and 2,3-Disubstituted Tetrahydrofuran Derivatives

A novel and convenient one-pot asymmetric synthesis of 2- and 2,3-disubstituted tetrahydrofurans has been achieved in 56–81% yields and 86–99% ee from aliphatic and aromatic aldehydes via an allyl/crotyl/alkoxyallylboration–hydroboration–iodination–cyclization reaction sequence.