One-Pot Total Synthesis of Evodiamine and Its Analogues through a Continuous Biscyclization Reaction
journal contributionposted on 04.10.2018, 13:34 by Zi-Xuan Wang, Jia-Chen Xiang, Miao Wang, Jin-Tian Ma, Yan-Dong Wu, An-Xin Wu
The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. The use of triethoxymethane as a cosolvent was crucial for this quick and straightforward transformation.