One-Pot Synthesis of 3‑Methyl-2-arylimidazo[1,2‑a]pyridines Using Calcium Carbide as an Alkyne Source

An efficient method for the construction of 3-methyl-2-arylimidazo­[1,2-a]­pyridines from the reactions of calcium carbide, 2-aminopyridines, and aromatic aldehydes is described. The notable advantages for this strategy include the use of an inexpensive and concise solid alkyne source, cheap and readily available raw materials, wide-scope substrates, and a simple work-up procedure.