jo9814546_si_001.pdf (1.61 MB)
On the Structure of Total Synthesis of Complex Natural Products
journal contribution
posted on 1998-10-06, 00:00 authored by H. W. WhitlockA chemically intuitive measure (metric) for molecular complexity is described. It is then applied
to several syntheses of complex natural products. We conclude that the metric corresponds well
with chemical ideas of complexity, and that different syntheses do in fact have appreciably different
logical structures as measured by this. Possible implications of this interesting observation are
discussed.