American Chemical Society
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Oleanane-Type Triterpenes from the Flowers and Roots of Saussurea muliensis

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journal contribution
posted on 2008-05-23, 00:00 authored by Chun-Mei Liu, He-Xiang Wang, Shi-Lei Wei, Kun Gao
Six new oleanane-type triterpenes (16), along with five known compounds, were isolated from the flowers and roots of Saussurea muliensis. On the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques, the structures of the new compounds were characterized as 3β,22α-dihydroxyolean-12-en-30-oic acid (1), 3α-(E)-caffeoyloxyolean-12-en-30-oic acid (2), 3α-(E)-coumaroyloxyolean-12-en-30-oic acid (3), 3α,22α-diacetoxy-20β,21α,29-trihydroxy-30-norolean-12-ene (4), 3α,22α-diacetoxy-21α,29-dihydroxy-20β-methoxy-30-norolean-12-ene (5), and 3α,22α-diacetoxy-20β,21α-dihydroxy-29-palmityloxy-30-norolean-12-ene (6). The isolated compounds (16) were not active against Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Candida albicans.