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Oleanane-Type Isomeric Triterpenoids from Barringtonia racemosa

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journal contribution
posted on 24.04.2009, 00:00 by P. Mangala Gowri, S. V. S. Radhakrishnan, S. Jeelani Basha, A. V. S. Sarma, J. Madhusudana Rao
Two new isomeric acylated oleanane-type triterpenoids along with three known compounds were isolated from the MeOH extract of the dried fruits of Barringtonia racemosa. On the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques as well as chemical methods, the structures were characterized as racemosol A (1) [22α-acetoxy-3β,15α,16α,21β-tetrahydroxy-28-(2-methylbutyryl)olean-12-ene] and isoracemosol A (2) [21β-acetoxy-3β,15α,16α,28-tetrahydroxy-22α-(2-methylbutyryl)olean-12-ene]. The isolated compounds (15) were not active against HeLa and P388 D1 carcinoma cell lines.