ol050796c_si_001.pdf (1.63 MB)
Download fileOceanalin A, a Hybrid α,ω-Bifunctionalized Sphingoid Tetrahydroisoquinoline β-Glycoside from the Marine Sponge Oceanapia sp.
journal contribution
posted on 2005-07-07, 00:00 authored by Tatyana N. Makarieva, Vladimir A. Denisenko, Pavel S. Dmitrenok, Alla G. Guzii, Elena A. Santalova, Valentin A. Stonik, John B. MacMillan, Tadeusz F. MolinskiThe novel antifungal compound oceanalin A, an unprecedented “hybrid sphingolipid”, was isolated from the marine sponge Oceanapia sp.
The structure was elucidated using NMR and MS spectral analysis and chemical degradation. Oceanalin A exhibits in vitro antifungal activity
against Candida glabrata with an MIC of 30 μg/mL.