Oceanalin A, a Hybrid α,ω-Bifunctionalized Sphingoid Tetrahydroisoquinoline β-Glycoside from the Marine Sponge Oceanapia sp.
journal contributionposted on 2005-07-07, 00:00 authored by Tatyana N. Makarieva, Vladimir A. Denisenko, Pavel S. Dmitrenok, Alla G. Guzii, Elena A. Santalova, Valentin A. Stonik, John B. MacMillan, Tadeusz F. Molinski
The novel antifungal compound oceanalin A, an unprecedented “hybrid sphingolipid”, was isolated from the marine sponge Oceanapia sp. The structure was elucidated using NMR and MS spectral analysis and chemical degradation. Oceanalin A exhibits in vitro antifungal activity against Candida glabrata with an MIC of 30 μg/mL.