jp8b03490_si_001.pdf (1.19 MB)
Observation of Ultrafast Vibrational Energy Transfer in Fibrinogen and Fibrin Fibers
journal contribution
posted on 2018-04-30, 00:00 authored by Biplab Dutta, Bart E. Vos, Yves L. A. Rezus, Gijsje H. Koenderink, Huib J. BakkerWe
study the secondary structure of the blood protein fibrinogen
using two-dimensional infrared spectroscopy. With this technique,
we identify the amide I′ vibrational modes of the antiparallel
β-sheets and turns of fibrinogen. We observe ultrafast energy
flow among these amide I′ vibrational modes with a time constant
of ∼7 ps. This energy transfer time constant does not change
significantly upon fibrin fiber formation, indicating that the secondary
structure of the fibrinogen monomers remains largely unchanged in
the polymerization process.