posted on 2023-11-14, 13:41authored byMahesh
S. Gadhave, Soumen Barik, Felix Wessels, Akkattu T. Biju
A general and practical route to the synthesis of functionalized
isoindolin-2-ones from commercially available aldehydes and 2-chlorobenzonitriles
under mild conditions initiated by N-heterocyclic carbenes is presented.
The catalytically generated Breslow intermediates from aldehydes and
carbenes underwent smooth SNAr with 2-chlorobenzonitriles
followed by annulation triggered by adventitious water present in
DMF to furnish the functionalized isoindolin-2-ones in good to excellent
yields.