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Nucleic Acid-Induced Aggregation and Pyrene Excimer Formation

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journal contribution
posted on 01.10.2009, 00:00 by Ruixing Zhang, Dan Tang, Ping Lu, Xiangyu Yang, Dongli Liao, Yujing Zhang, Mingjun Zhang, Cong Yu, Vivian W. W. Yam
Nucleic acid was found to induce the aggregation of the positively charged pyrene probe (compound 1); as a result, strong pyrene excimer emission was observed. The intensity of the excimer emission was dependent on the concentration of the pyrene probe and the oligonucleotide length, sequence, and concentration. These results suggest a new strategy for label-free nucleic acid-based biosensing applications.