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Download fileNucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties
journal contribution
posted on 21.04.2016, 21:04 authored by Elena Pazos, Eduard Sleep, Charles
M. Rubert
Pérez, Sungsoo S. Lee, Faifan Tantakitti, Samuel I. StuppSilver
nanoparticles have been of great interest as plasmonic substrates
for sensing and imaging, catalysts, or antimicrobial systems. Their
physical properties are strongly dependent on parameters that remain
challenging to control such as size, chemical composition, and spatial
distribution. We report here on supramolecular assemblies of a novel
peptide amphiphile containing aldehyde functionality in order to reduce
silver ions and subsequently nucleate silver metal nanoparticles in
water. This system spontaneously generates monodisperse silver particles
at fairly regular distances along the length of the filamentous organic
assemblies. The metal–organic hybrid structures exhibited antimicrobial
activity and significantly less toxicity toward eukaryotic cells.
Metallized organic nanofibers of the type described here offer the
possibility to create hydrogels, which integrate the useful functions
of silver nanoparticles with controllable metallic content.
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Keywords
plasmonic substratesHybrid Nanostructureschemical compositioneukaryotic cellsaldehyde functionalityantimicrobial systemsantimicrobial activitysilver ionsSilver Nanoparticlessupramolecular assembliesPeptide NanofibersAntimicrobial Properties Silver nanoparticlesnucleate silver metal nanoparticlesassemblynovel peptide amphiphilesilver nanoparticlessilver particles