American Chemical Society
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Nuclease Activity via Self-Activation and Anticancer Activity of a Mononuclear Copper(II) Complex: Novel Role of the Tertiary Butyl Group in the Ligand Frame

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journal contribution
posted on 2012-03-19, 00:00 authored by Kaushik Ghosh, Pramod Kumar, Varun Mohan, Udai P. Singh, Sahba Kasiri, Subhrangsu S. Mandal
The copper complex [Cu­(tBuPhimp)­(Cl)] (1) derived from tridentate ligand tBuPhimpH having N2O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce­(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.