ic2016676_si_003.pdf (518.96 kB)
Nuclease Activity via Self-Activation and Anticancer Activity of a Mononuclear Copper(II) Complex: Novel Role of the Tertiary Butyl Group in the Ligand Frame
journal contribution
posted on 2012-03-19, 00:00 authored by Kaushik Ghosh, Pramod Kumar, Varun Mohan, Udai P. Singh, Sahba Kasiri, Subhrangsu
S. MandalThe copper complex [Cu(tBuPhimp)(Cl)] (1) derived from tridentate ligand tBuPhimpH having
N2O donors was synthesized, and its molecular structure
was
determined. A phenoxyl radical complex was generated in solution at
room temperature using Ce(IV). The nuclease and anticancer activities
of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were
also discussed.
