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Download fileNovel and Versatile Synthesis of Disubstituted 1,2-Dihydro-1,2,4-triazol-3-ones
journal contribution
posted on 2013-12-06, 00:00 authored by Mark A. Graham, Paul A. Bethel, Jonathan Burgess, Gary Fairley, Steve C. Glossop, Ryan D. R. Greenwood, Clifford D. Jones, Scott Lovell, Steve SwallowA novel method for the synthesis of a wide range of 1,5-disubstituted
1,2-dihydro-1,2,4-triazol-3-ones is described. The key step involves
a reaction between a dilithiated BOC-hydrazine and a N-alkoxycarbonylcarboximidothioate. A broad range of aryl and alkyl
functional groups are tolerated, providing a versatile route for the
synthesis of triazolones.
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