posted on 2013-12-06, 00:00authored byMark A. Graham, Paul A. Bethel, Jonathan Burgess, Gary Fairley, Steve C. Glossop, Ryan D. R. Greenwood, Clifford D. Jones, Scott Lovell, Steve Swallow
A novel method for the synthesis of a wide range of 1,5-disubstituted
1,2-dihydro-1,2,4-triazol-3-ones is described. The key step involves
a reaction between a dilithiated BOC-hydrazine and a N-alkoxycarbonylcarboximidothioate. A broad range of aryl and alkyl
functional groups are tolerated, providing a versatile route for the
synthesis of triazolones.