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Novel Synthesis of Substituted Furo[3,2‑c]chromen-4-ones via Four-component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Coumarins, and Ammonium Acetate

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posted on 08.07.2013, 00:00 by Zhengquan Zhou, Hui Liu, Yun Li, Juanjuan Liu, Yan Li, Jinliang Liu, Juan Yao, Cunde Wang
An efficient and direct synthesis of 2-arylideneamino-3-aryl-4H-furo­[3,2-c]­chromen-4-ones has been developed via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, and ammonium acetate under very mild conditions, which involves sequentially a Michael addition, an aza-nucleophilic addition, of the imine to the double bond, an intermolecular nucleophilic addition and a dehydration reaction. The resulting biologically intriguing structures could have broad applications in related biomedical-program structures.