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Novel Chiral Dendritic Diphosphine Ligands for Rh(I)-Catalyzed Asymmetric Hydrogenation:  Remarkable Structural Effects on Catalytic Properties

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journal contribution
posted on 29.04.2004, 00:00 by Bing Yi, Qing-Hua Fan, Guo-Jun Deng, Yue-Ming Li, Li-Qin Qiu, Albert S. C. Chan
A series of dendritic ligands with a chiral diphosphine located at the focal point have been synthesized through coupling of pyrphos 2 with Fréchet-type polyether dendron 3. The relationship between the primary structure of the dendrimer and its catalytic properties was established in the Rh-catalyzed asymmetric hydrogenation of α-acetamido cinnamic acid 4. A remarkable structural effect on catalytic activity was observed.