Novel Bromotyrosine Alkaloids: 
Inhibitors of Mycothiol S-Conjugate
Amidase

Nicholas, Gillian M.; Newton, Gerald L.; Fahey, Robert C.; Bewley, Carole A.

doi:10.1021/ol015845+.s001

Novel Bromotyrosine Alkaloids: Inhibitors of Mycothiol S-Conjugate Amidase

journal contribution

posted on 2001-04-21, 00:00 authored by Gillian M. Nicholas, Gerald L. Newton, Robert C. Fahey, Carole A. Bewley

The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp. Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro-isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA).

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Compound 1 conjugate amidase substructure Inhibitor Bromotyrosine Conjugate Amidase Alkaloid Mycothiol S Oceanapia sp MCA novel alkaloids 1 mycobacterial enzyme mycothiol S inhibitor

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Novel Bromotyrosine Alkaloids: Inhibitors of Mycothiol S-Conjugate Amidase

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