co300141j_si_001.pdf (270.07 kB)
Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives
journal contribution
posted on 2016-02-19, 09:14 authored by Afsaneh Zonouzi, Fatemeh Hosseinzadeh, Nastaran Karimi, Roghieh Mirzazadeh, Seik Weng NgA library of some new fluorescent
chromenopyrimidine derivatives
has been synthesized by new approaches. Water-promoted and one-pot
reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced
using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno[2,3-d]-pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2,
3-d]pyrimidines are synthesized by Lewis-acid
catalyzed reactions. The fluorescence emission intensity of the four
compounds from each of libraries after excitation in 290 nm is measured.
Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The
details of an interesting exchangeable intramolecular H- bonding of
two of the new compounds are reported by X-ray analysis data.