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Nonterpenoid C15 Acetogenins from Laurencia marilzae

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journal contribution
posted on 25.03.2011, 00:00 by Adrián Gutiérrez-Cepeda, José J. Fernández, Laura V. Gil, Matías López-Rodríguez, Manuel Norte, María L. Souto
Eight new halogenated C15 acetogenins, 18, were isolated from the organic extract of the red alga Laurencia marilzae. The structure elucidation and the assignments of the relative configurations were established by extensive use of spectroscopic studies, particularly 1D and 2D NMR data, while the absolute configurations of compounds 1 and 5 were determined by single-crystal X-ray diffraction analysis. Compounds 1, 2, 4, 5, and 7, along with the previously reported related cyclic ether obtusallene IV (9), were evaluated against six human solid tumor cell lines. All compounds were found to be essentially inactive (GI50 > 10 μg/mL).