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Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene

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journal contribution
posted on 18.07.2014, 00:00 by Suresh Kumar Sythana, Surendra R. Naramreddy, Santosh Kavitake, Vinod Kumar CH., Pundlik R. Bhagat
A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.