Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue
journal contribution
posted on 2018-04-16, 00:00 authored by Anthony
D. Santilli, Elizabeth M. Dawson, Kristi J. Whitehead, Daniel C. WhiteheadA new
approach for the nonmicrobicidal phenotypic manipulation
of prominent gastrointestinal microbes is presented. Low micromolar
concentrations of a chemical probe, acarbose, can selectively inhibit
the Starch Utilization System and ablate the ability of Bacteroides
thetaiotaomicron and B. fragilis strains
to metabolize potato starch and pullulan. This strategy has potential
therapeutic relevance for the selective modulation of the GI microbiota
in a nonmicrobicidal manner.
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relevanceGI microbiotanonmicrobicidal phenotypic manipulationacarboseStarch Utilization SystemabilityNonmicrobicidalPolysaccharide MetabolismPotential Therapeutic AvenuestrategyLow micromolar concentrationsapproachchemical probenonmicrobicidal mannerMolecule InhibitionmodulationHuman Gut Microbesfragilis strainsablatemicrobeBacteroides thetaiotaomicronpullulanpotato starch
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