Nitrogen Atom Transfer Enables the (5+1) Annulation Reaction to Access Aminoisoquinolines

Herein, a catalytic synthetic transformation offering a series of -NH₂ group-bearing aminoisoquinolines with moderate to good yields has been showcased. Interestingly, the nitrogen atom of the isoquinoline ring is coming from the reaction medium upon metal-assisted CN bond cleavage. Moreover, this (5+1) annulation reaction shows broad substrate variation. Furthermore, the derivatization of the isoquinoline core via functional group interconversions and mechanistic studies to identify the reaction intermediate have been carried out successfully.