posted on 2023-03-22, 20:04authored byYang Li, Lijun Li, Changyou Guo, Qinqin Yan, Hongxun Zhou, Ying Wang, Zhong-Quan Liu, Zejiang Li
A metal/peroxide-free involved simple cascade 6-exo-trig spirocyclization of tert-butyl
nitrite with
biaryl ynones has been finished, which resulted in various NO2-modified spiro[5,5]trienones with good regioselectivity/yields.
A variety of scaled-up experiments, reduction/epoxidation operations,
and mechanistic studies were performed to verify the merits and spirocyclization
process of this radical system. Finally, the structure of the spirocycles
was confirmed by single-crystal X-ray diffraction.