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Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p‑Toluenesulfonate

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journal contribution
posted on 05.07.2018, 01:29 by Kimihiro Komeyama, Yuta Yamahata, Itaru Osaka
Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide range of CD3-containing arenes. Moreover, a transmethylation step is revealed as crucial in the nickel/cobalt catalytic mechanism.

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