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Download fileNickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p‑Toluenesulfonate
journal contribution
posted on 2018-07-05, 01:29 authored by Kimihiro Komeyama, Yuta Yamahata, Itaru OsakaHerein, a novel approach
for the trideuteriomethylation of aryl
halides using nickel and nucleophilic cobalt catalysts and the readily
available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide range
of CD3-containing arenes. Moreover, a transmethylation
step is revealed as crucial in the nickel/cobalt catalytic mechanism.