ol8b01863_si_001.pdf (1.6 MB)
Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p‑Toluenesulfonate
journal contributionposted on 2018-07-05, 01:29 authored by Kimihiro Komeyama, Yuta Yamahata, Itaru Osaka
Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide range of CD3-containing arenes. Moreover, a transmethylation step is revealed as crucial in the nickel/cobalt catalytic mechanism.