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Nickel-Catalyzed Direct C (sp3)–H Arylation of Aliphatic Amides with Thiophenes

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journal contribution
posted on 06.11.2015, 00:00 by Xie Wang, Longzhi Zhu, Sihai Chen, Xinhua Xu, Chak-Tong Au, Renhua Qiu
Nickel-catalyzed heteroarylation of the inactive methyl C­(sp3)–H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.