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Nickel(0)-Mediated Sequential Addition of Carbon Dioxide and Aryl Aldehydes into Terminal Allenes

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journal contribution
posted on 26.06.2003, 00:00 by Masanori Takimoto, Mitsunobu Kawamura, Miwako Mori
Nickel-mediated sequential addition of carbon dioxide and aryl aldehydes into terminal allenes is reported. The reaction proceeded in a diastereoselective manner to afford α-methylene-γ-hydroxy carboxylic acids, which allowed stereoselective preparation of cis-β,γ-disubstituted α-methylene-γ-lactones.