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Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides

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journal contribution
posted on 29.08.2019, 18:33 by Zhenhua Wang, Xiu Wang, Yasuyuki Ura, Yasushi Nishihara
Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.