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Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide

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journal contribution
posted on 26.03.2019, 11:37 authored by Cong Ma, Chuan-Qi Zhao, Xue-Tao Xu, Zhao-Ming Li, Xiang-Yang Wang, Kun Zhang, Tian-Sheng Mei
The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.