Ni-Catalyzed
Direct Reductive Amidation via C–O
Bond Cleavage

Correa, Arkaitz; Martin, Ruben

doi:10.1021/ja5029793.s001

Ni-Catalyzed Direct Reductive Amidation via C–O Bond Cleavage

journal contribution

posted on 2014-05-21, 00:00 authored by Arkaitz Correa, Ruben Martin

A novel Ni-catalyzed reductive amidation of C(sp²)–O and C(sp³)–O electrophiles with isocyanates is described. This umpolung reaction allows for an unconventional preparation of benzamides using simple starting materials and easy-to-handle Ni catalysts.

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Ni Reductive Amidation reductive CleavageA amidation electrophile material umpolung reaction isocyanate catalyst Bond preparation benzamide

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CC BY-NC 4.0

Ni-Catalyzed Direct Reductive Amidation via C–O Bond Cleavage

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