American Chemical Society
cs2c04412_si_001.pdf (7.38 MB)

Ni-Catalyzed Site-Selective Hydrofluoroalkylation of Terminal and Internal Olefins

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journal contribution
posted on 2022-09-21, 14:10 authored by Wen-Jun Yue, Ruben Martin
A catalytic monofluoroalkylation of terminal and internal olefins is described. This protocol is distinguished by its mild conditions, wide scopeincluding the utilization of chemical feedstocks and advanced intermediatesand exquisite site-selectivity for both α-olefins and internal olefins. In the latter, C–C bond formation occurs at remote sp3 C–H sites, thus unlocking a blueprint for incorporating monofluorinated alkyl chains that complements existing techniques occurring at sp3 centers.