om1c00096_si_001.pdf (5.55 MB)

Ni-Catalyzed Coupling of Butadiene, Aldimines, and Arylboronic Acids to Homoallylic Amines under Base-Free Conditions

Download (5.55 MB)
journal contribution
posted on 31.03.2021, 08:29 by Yu-Qing Li, Shi-Liang Shi
Herein, we report a nickel-catalyzed three-component coupling of butadiene, aldimines, and arylboronic acids to form synthetically important homoallylic amines. The starting materials are stable and readily available; especially, butadiene is an abundant chemical feedstock. This protocol provides rapid access to various (E)-homoallylic amines with excellent regio- and stereoselectivity by constructing two C–C bonds simultaneously. The mild and base-free reaction condition enables a broad substrate scope and high functional group tolerance for both aldimine and arylboronic acid coupling parts.