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Ni-Catalyzed Coupling of Butadiene, Aldimines, and Arylboronic Acids to Homoallylic Amines under Base-Free Conditions

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journal contribution
posted on 31.03.2021, 08:29 by Yu-Qing Li, Shi-Liang Shi
Herein, we report a nickel-catalyzed three-component coupling of butadiene, aldimines, and arylboronic acids to form synthetically important homoallylic amines. The starting materials are stable and readily available; especially, butadiene is an abundant chemical feedstock. This protocol provides rapid access to various (E)-homoallylic amines with excellent regio- and stereoselectivity by constructing two C–C bonds simultaneously. The mild and base-free reaction condition enables a broad substrate scope and high functional group tolerance for both aldimine and arylboronic acid coupling parts.

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