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New Rofecoxib-Based Mechanochromic Luminescent Materials and Investigations on Their Aggregation-Induced Emission, Acidochromism, and LD-Specific Bioimaging

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journal contribution
posted on 21.02.2022, 19:08 authored by Liwei Chen, Renfu Li, Xinli Wang, Zexin Wang, Xiang Lin, Lu Yang, Yunpeng Yao, Shitao Sun, Zhenli Li, Jinle Hao, Bin Lin, Xueyuan Chen, Lijun Xie
Development of new mechanochromic luminescent (MCL) materials from aggregation-induced emission luminogens (AIEgens) has attracted wide attention due to their potential application in multiple areas. However, rational design and crafting of new MCL materials from the simple AIEgens skeleton is still a big challenge because of the undesirable concentration quenching effect. In this study, we have constructed a new class of MCL materials by adding one phenyl as a new rotator and incorporating one pair of electron donor (D) and acceptor (A) into the system of rofecoxib skeleton. This strategy endowed the compounds (Y1Y8) with tunable emission behavior and some of them with the AIE effect and reversible MCL behavior. These properties may be caused by the highly twisted conformation and loosely molecular packing modes, which were elucidated clearly by analyzing the data of single-crystal X-ray diffraction, powder X-ray diffraction, and differential scanning calorimetry. Further investigation revealed that Y7 displayed acidochromic property due to the protonation of the nitrogen atom. Moreover, Y7, as a typical compound, showed its potential applications in the area of anticounterfeiting, pH sensor, and LD-specific bioimaging.