New Oplopane and Eremophilane Derivatives from Robinsonecio gerberifolius§
journal contributionposted on 17.01.2003, 00:00 by Amira Arciniegas, Ana-L. Pérez-Castorena, Sibet Reyes, José Luis Contreras, Alfonso Romo de Vivar
A phytochemical study of Robinsonecio gerberifolius afforded six new sesquiterpenoids, two oplopane (1 and 2) and four eremophilane derivatives (3−6). The structures of these compounds were elucidated on spectroscopic grounds, and the absolute configurations of compounds 3 and 4 were established from CD analysis. The known 3β-angeloyloxy-1,10-epoxyfuranoeremophilane (7) was also isolated, and its stereochemistry was revised. The cytotoxic activities of compounds 1−7 were determined against five human cancer cell lines.