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New Oplopane and Eremophilane Derivatives from Robinsonecio gerberifolius§

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journal contribution
posted on 17.01.2003, 00:00 by Amira Arciniegas, Ana-L. Pérez-Castorena, Sibet Reyes, José Luis Contreras, Alfonso Romo de Vivar
A phytochemical study of Robinsonecio gerberifolius afforded six new sesquiterpenoids, two oplopane (1 and 2) and four eremophilane derivatives (36). The structures of these compounds were elucidated on spectroscopic grounds, and the absolute configurations of compounds 3 and 4 were established from CD analysis. The known 3β-angeloyloxy-1,10-epoxyfuranoeremophilane (7) was also isolated, and its stereochemistry was revised. The cytotoxic activities of compounds 17 were determined against five human cancer cell lines.