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New Indole Alkaloids from the Roots of Ochrosia acuminata

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journal contribution
posted on 22.10.2004, 00:00 by Angela A. Salim, Mary J. Garson, David J. Craik
Two new indole alkaloids, polyneuridine-N-oxide (1) and 17-hydroxy-10-methoxy-yohimbane (2), together with seven known alkaloids were isolated from the roots of Ochrosia acuminata collected in Savu, Indonesia. 9-Methoxyellipticine (3) and ellipticine (4) were responsible for the antitumor activities of the extract. The structures of all compounds were elucidated using MS and NMR methods.