ja2056159_si_002.pdf (2.67 MB)

New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C–N Bond Formation

Download (2.67 MB)
journal contribution
posted on 05.10.2011, 00:00 by Wei Li, Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin, Changwei Hu, Lili Lin, Xiaoming Feng
α-Diazoesters were discovered to be good electrophiles in a catalytic asymmetric α-functionalization of ketones for the first time. This reaction also provided a direct and efficient method for C–N bond formation with excellent yields (up to 98%) and enantioselectivities (up to 99% ee) under mild conditions. The application of the electrophilicity of α-diazoesters opens up a novel way to access the diversity of diazo chemistry.