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New Candidaspongiolides, Tedanolide Analogues That Selectively Inhibit Melanoma Cell Growth

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journal contribution
posted on 01.07.2011, 00:00 by Emily L. Whitson, Kristen M. Pluchino, Matthew D. Hall, James B. McMahon, Tawnya C. McKee
Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.