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New Antimicrobial Cyclopentenones from Nigrospora sphaerica ZMT05, a Fungus Derived from Oxya chinensis Thunber

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journal contribution
posted on 10.05.2018, 00:00 by Zhihui Wu, Zihui Xie, Manlin Wu, Xiaoqi Li, Weilin Li, Weijia Ding, Zhigang She, Chunyuan Li
Six new cyclopentenone derivatives (+)-nigrosporione A (+)-1, (−)-nigrosporione A (−)-1, nigrosporione B (2), nigrosporione C (3), (+)-nigrosporione D (+)-4, and (−)-nigrosporione D (−)-4 were isolated from an endophytic fungus Nigrospora sphaerica ZMT05, collected from the rice grasshopper (Oxya chinensis Thunberg), which is an insect pest in rice and which is also used as a food for people in some countries. Their planar and spatial structures were determined by spectroscopic analyses and eletronic circular dichroism (ECD) calculations. Compounds (+)-1, (−)-1, and 2 inhibited the plant pathogens Fusarium oxysporum, Colletotrichum musae, Penicillium italicum, and Fusarium graminearum, compounds 3 and (−)-4 inhibited F. oxysporum, C. musae, and P. italicum, and compound (+)-4 inhibited F. oxysporum, C. musae, and F. graminearum, showing antifungal activities stronger than triadimefon. Additionally, compounds (+)-1, (−)-1, 2, and 3 displayed moderate antibacterial activities against Staphyloccocus aureus and Escherichia coli.

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