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Download fileNear-Infrared Quantum Dot and 89Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging
journal contribution
posted on 2016-12-27, 00:00 authored by Yiming Zhao, Travis M. Shaffer, Sudeep Das, Carlos Pérez-Medina, Willem J. M. Mulder, Jan GrimmCerenkov
luminescence (CL) is an emerging imaging modality that
utilizes the light generated during the radioactive decay of many
clinical used isotopes. Although it is increasingly used for background-free
imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here,
we propose to use quantum dots (QDs) as spectral converters that can
transfer the CL UV-blue emissions to near-infrared light that is less
scattered or absorbed in vivo. Experiments on tissue
phantoms showed enhanced penetration depth and increased transmitted
intensity for CL in the presence of near-infrared (NIR) QDs. To realize
this concept for in vivo imaging applications, we
developed three types of NIR QDs and 89Zr dual-labeled
nanoparticles based on lipid micelles, nanoemulsions, and polymeric
nanoplatforms, which enable codelivery of the radionuclide and the
QDs for maximized spectral conversion efficiency. We finally demonstrated
the application of these self-illuminating nanoparticles for imaging
of lymph nodes and tumors in a prostate cancer mouse model.
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background-free imagingprostate cancer mouse modelNear-Infrared Quantum Dotuse quantum dotsnear-infrared lightvivo imaging applicationslymph nodeslipid micellesself-illuminating nanoparticles89 Zr dual-labeled nanoparticlestissue phantomsvivo applicationstissue photodynamic therapyVivo Cerenkov Imaging Cerenkov luminescenceimaging modalityconversion efficiency89 Zr Dual-Labeled NanoparticlesNIR QDspenetration depthCL UV-blue emissionstissue penetration