Titanium dioxide (TiO2) has attracted significant attention
in the fields of antibacterial activity and pollutant degradation
due to its well-known photocatalytic properties. However, the application
of TiO2 is significantly limited by its large band gap
width, which only allows excitation by ultraviolet light below 400
nm. Here, we propose the use of surface chiral functionalization of
TiO2 to tune its band gap width, thus enabling it to be
excited by near-infrared-region light (NIR), resulting in the effective
separation of electron–hole pairs. By controlling the solvent
polarity and forming numerous weak interactions (such as hydrogen
bonding) between chiral ligands and TiO2, we successfully
prepared chiral TiO2 superparticles (SPs) that exhibited
a broad circular dichroism (CD) absorption at 792 nm. Under circularly
polarized light (CPL) at 808 nm, the chiral SPs induced the separation
of electron–hole pairs in TiO2, thus generating
hydroxyl and singlet oxygen radicals. Antibacterial tests under CPL
in NIR showed that the chiral TiO2 SPs exhibited excellent
antibacterial performance, with inhibition rates of 99.4% and 100%
against Gram-positive and Gram-negative bacteria, respectively. Recycling–reuse
experiments and biocompatibility evaluation of the material demonstrated
that the chiral TiO2 SPs are stable and safe antibacterial
materials, thus indicating the potential application of chiral TiO2 SPs in antibacterial aspects of medical implants.