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Nakadomarin A, a Novel Hexacyclic Manzamine-Related Alkaloid from Amphimedon Sponge

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journal contribution
posted on 26.12.1997, 00:00 by Jun'ichi Kobayashi, Daisuke Watanabe, Naoko Kawasaki, Masashi Tsuda
A novel manzamine-related alkaloid consisting of unprecedented 8/5/5/5/15/6 ring system, nakadomarin A (1), has been isolated from an Okinawan marine sponge Amphimedon sp., and the unique structure containing a furan ring was elucidated on the basis of the spectroscopic data. The relative stereochemistry was deduced from the NOE data and proton couplings, and a plausible biogenetic path of 1 through ircinal A was proposed.

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