Nagelamides X–Z, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
journal contributionposted on 19.02.2016, 04:15 by Naonobu Tanaka, Taishi Kusama, Azusa Takahashi-Nakaguchi, Tohru Gonoi, Jane Fromont, Jun’ichi Kobayashi
Three new dimeric bromopyrrole alkaloids, nagelamides X–Z (1–3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1–3 were elucidated on the basis of spectroscopic data. Nagelamides X–Z (1–3) exhibited antimicrobial activity.