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Download fileNaGdF4:Nd@NaGdF4 Core-Shell Down-Conversion Nanoparticles as NIR-II Fluorescent Probes for Targeted Imaging of Bacteria
journal contribution
posted on 08.10.2021, 05:03 authored by Leilei Sun, Sisi Shi, Hongchao Geng, Yao Huang, Yan Qiao, Jie Song, Lan Yang, Craig A. Grimes, Xinxin Feng, Qingyun CaiBacterial
infections are a serious ongoing threat to human health.
As such, within the context of modern technology, there is an urgent
need to develop fluorescent probes suitable for diagnosing bacterial
infections in vivo. Herein, we synthesize NaGdF4:Nd@NaGdF4 core-shell down-conversion nanoparticles (DCNPs) demonstrating
excellent emission intensity in the second near-infrared (NIR-II)
window for use as fluorescent probes to enable high-quality imaging
of pathogenic infections. The fluorescent probe is covalently linked
with vancomycin (Van), which specifically binds to Gram-positive bacteria
such as S. aureus. Both in vitro detection
and in vivo imaging results show that the Van-modified NIR-II fluorescent
probe can distinguish Gram-positive from Gram-negative bacteria with
a high degree of selectivity. Biocompatibility is verified by MTT
assay and histological analyses.
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serious ongoing threatdiagnosing bacterial infectionsbacteria bacterial infections4 </ subii fluorescent probesii fluorescent probefluorescent probesfluorescent probepathogenic infectionsnegative bacteriavitro detectionurgent needtargeted imagingspecifically bindssecond nearquality imagingmtt assaymodern technologyhuman healthhistological analyseshigh degreeenable highcovalently linkedconversion nanoparticles